Innovative Research

Dr. Miriam Cremer has received research awards from the National Institutes of Health (NIH), the Rising Tide Foundation, and the Gateway Foundation for Cancer Research through her work at the Cleveland Clinic. The goal of these projects is to collaborate with industry partners to develop and test screening and treatment devices for cervical precancer that can be utilized in low-resource settings.

BHI has participated as a subcontractor in these projects since 2015. Our members have presented preliminary results at various international conferences. We have also conducted hands-on demonstration workshops that have been overwhelmingly well-received by medical providers.

These studies are currently taking place in El Salvador, China, and Colombia, with potential new sites to be added in the coming year.

The technologies in development include portable treatment devices that have the potential to revolutionize the field of cervical cancer prevention by making treatment available in even the most remote locations.

LMIC-Adapted Cryopen®

Instead of using cryogenic gas like conventional cryotherapy, the Cryopen® (CryoPen Inc., Southlake, TX) utilizes electricity or power from a car battery to freeze cervical precancer lesions.

Thermal Ablation

This highly portable device (WiSAP Medical Technologies GmbH, Brunnthal, Germany) uses heat instead of cold to treat cervical precancer.

EVA System

This cell phone-based colposcope (MobileODT, Tel Aviv, Israel) allows clinicians to conduct gynecologic exams in any location, and to perform real-time remote consultations when an internet connection is available.

Mobile ODT

As part of our compromise to adapt new technologies to the national health system; we donated 30 Mobile ODTs with EVA System to the Ministry of Health of El Salvador for CAPE project. These portable devices can help doctors perform gynecological exams in any location; including rural clinics in remote areas. Innovative technologies like this one are crucial in bringing preventive services to more underserved women. Doctors can make inter-consultations in real time with a specialist (colposcopist) for a better evaluation, immediate results and treatment. Now patients don’t have to wait two months to receive their treatment.

HRME: High Resolution Micro Endoscopy

The HRME imaging system is intended to be a low-cost, innovative technique that allows real-time, point-of-care detection of high-grade precancerous cervical lesions without a biopsy being performed. To date, we have enrolled more than 900 women in this project.

Cervical Cancer Screening in Transgender Men

BHI conducted one of the first studies testing the acceptability of HPV tests as a cervical cancer screening method among transgender men in a LMIC.

In partnership with the non profit organization Generación Hombres Trans of San Salvador, we offered HPV self-collected tests and comprehensive physical exams to transgender men. Most of them accepted the HPV self-collection. We hope that the use of HPV self-sampling tests in transgender men is a viable method that can significantly improve the participation and acceptance of cervical cancer screening in a LMIC setting.